Authors: | Date：2010-09-02 08:34:00

PhD dissertation titled as "Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity" with the A&F's Ph.D. Student Li Jia as the first author and the A&F as the second publication unit was officially published in Cell Metabolism, a world famous journal on August 4th, 2010.

Li Jia was a 2007's postgraduate student majored in Animal Biotechnology in College of Animal Science, the A&F. She started Ph.D education under the guide of Prof. Wang Huayan in College of Veterinary Medicine. In September, 2008, after the education of undergraduate, postgraduate and the first year of Ph.D. as well as the experience in the laboratory, she went to Pennsylvania State University, America on "Chinese Government Graduate Student Overseas Study Program" and was co-cultivated in the laboratory of Prof. Shi Yuguang in the university.

Diabetes is one of the main diseases that are seriously harmful to human life. As the human being get higher living standards, there are an increasing number of diabetics, which has become one of the major problems faced by the medical community. Li Jia focuses on the research on the pathogenesis in DiabetesⅡby the molecular level, and expounds for the first time that there is a close relationship among the major gene--ALCAT1 in the regulatory mechanism of cell mitochondria, the stress response of reactive oxygen species and function failing of mitochondria. The increase of ALCAT1 when oxidative stress and diet give rise to obesity causes the  mitochondria dysfunction in cells, the production of active oxygen, antagonism of insulin, etc., which finally causes the symptom of DiabetesⅡ. However, rats whose ALCAT1 are removed are exception. The above finding is of great importance in the study on nosogenesis of diabetes, obesity and other metabolic disease. 

Prof. Zhi Yuguang is the lifetime professor and supervisor of Ph.D. students in Pennsylvania State University and visiting professor of the A&F. He graduated form the A&F in 1982, and pursued his master degree of genetics in University of New England in Australia and his Ph.D. degree of molecular biology in Australian National University; he also engaged in post-doctoral study in University of California, San Francisco. Prof. Shi Yuguang is a member of Project Review Committee in American National Institutes of Health, Organizing Meeting member of Annual Meeting of Paris Anti- Obesity Therapies, member of editorial board of American Journal of Physiology and Journal of Molecular & Cellular Biochemistry. Prof. Shi engages himself in molecular biology and molecular regulation of endocrine genes, and leads the world in the study on obesity and diabetes. He has the originality in the study on the development of the biological target of drugs, degeneration of cardiolipin and mitochondrial, and signal transduction of blood glucose sensor of pancreatic island β cell, etc. Prof. Shi has published dozens of papers in world class journals and has an impact factor of over 300. Prof. Shi is the corresponding author of Li jia's paper "Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity".

Prof. Wang Huayan, supervisor of Ph.D. students, is one of the authors of the paper. He now holds a position as Dean of Department of Animal Biotechnology in College of Animal Science, the A&F, and Director of Institute of Shaanxi Provincial Stem Cell Engineering Technology, etc. Prof. Wang graduated from the A&F with a bachelor's degree, and gained doctor's degree of molecular genetics in Department of Genetics in Trinity College, University College Dublin, Ireland. He once engaged in post-doctoral study in Department of Clinical Medicine in University of Alberta, Canada. Prof. Wang focused on the study of animal stem cell engineering, animal embryo engineering, transgenic animal cloning, etc. He has made a lot of academic achievements in stem cell biology and induced differentiation, animal embryo cloning, etc.

The journal of Cell Metabolism, the sister journal of world's leading biology journal Cell, is published monthly. It published original research reports in all areas of metabolic biology, covering research from molecular biology and cytobiology to preclinical study.

                      

Translated by: Yang Limiao

Proofread by: Yang Xiaofeng

Edited by: Yang Yaorong